Serum Amyloid A as a Predictor of Coronary Artery Disease and Cardiovascular Outcome in Women

نویسندگان

  • Paul M Ridker
  • Sheryl F. Kelsey
  • Leslee J. Shaw
  • Barry Sharaf
  • Noel Bairey Merz
  • Marian B. Olson
  • Steven E. Reis
چکیده

Background—Serum amyloid(SAA) is a sensitive marker of an acute inflammatory state. Like high-sensitivity C-reactive protein (hs-CRP), SAA has been linked to atherosclerosis. However, prior studies have yielded inconsistent results, and the independent predictive value of SAA for coronary artery disease (CAD) severity and cardiovascular events remains unclear. Methods and Results—A total of 705 women referred for coronary angiography for suspected myocardial ischemia underwent plasma assays for SAA and hs-CRP, quantitative angiographic assessment, and follow-up evaluation. Cardiovascular events were death, myocardial infarction, congestive heart failure, stroke, and other vascular events. The women’s mean age was 58 years (range 21 to 86 years), and 18% were nonwhite. SAA and hs-CRP were associated with a broad range of CAD risk factors. After adjustment for these risk factors, SAA levels were independently but moderately associated with angiographic CAD (P 0.004 to 0.04) and highly predictive of 3-year cardiovascular events (P 0.0001). By comparison, hs-CRP was not associated with angiographic CAD (P 0.08 to 0.35) but, like SAA, was strongly and independently predictive of adverse cardiovascular outcome (P 0.0001). Conclusions—Our results show a strong independent relationship between SAA and future cardiovascular events, similar to that found for hs-CRP. Although SAA was independently but moderately associated with angiographic CAD, this association was not found for hs-CRP. These results are consistent with the hypothesis that systemic inflammation, manifested by high SAA or hs-CRP levels, may promote atherosclerotic plaque destabilization, in addition to exerting a possible direct effect on atherogenesis. (Circulation. 2004;109:726-732.)

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Correlation Between Aortic Valve Sclerosis and Coronary Artery Disease: A Cross - Sectional Study

  Introduction: Aortic valve sclerosisis considered as a manifestation of coronary atherosclerosis. Recent studies demonstrated an association between aortic valve sclerosis and obstructive coronary artery disease. The purpose of this study was to evaluatethe correlation betweenaortic valve sclerosis andobstructive coronary artery disease and the extent of coronary artery disease in patients ho...

متن کامل

Predictors of Diet Self-efficacy in Coronary Artery Disease Patients

Introduction: Coronary artery disease is one of the most prevalent cardiovascular diseases in developed countries. Following a healthy diet and lifestyle decline emergence of the disease complication and readmission rate due to unstable angina and myocardial infarction. Promotion of self-efficacy after a cardiovascular event is the outcome that plays a vital role in increasing rehabilitation sk...

متن کامل

Evaluation of the Relationship Between Hot Flashes and Night Sweats and Severity of Coronary Artery Disease in Postmenopausal Women

Introduction: Hot flashes (HF) and night sweats (NS) are due to vasomotor instability and could be recognized as cardiovascular risk markers. Therefore, this study aimed to evaluate the relationship between vasomotor instability and severity of coronary artery disease (CAD) in postmenopausal women.  Materials and Methods: This observational cross sectional study, was performed in Chamran Hospit...

متن کامل

Maternal and Fetal Outcomes in Pregnant Women with Cardiac Diseases Presenting to Shariati Hospital Cardiovascular Department from 21st March 2017 to 20th March 2018

Background: Cardiac diseases are considered as major cause of maternal mortality during pregnancy and account for about 10% of all maternal mortalities. Cardiac diseases cause complications for both mother and fetus. In this study, we evaluated the effects of cardiac diseases on pregnancy and vice versa. Three groups of complications were examined: complication of maternal heart (serious and li...

متن کامل

ارتباط سطح اسید اوریک سرم با بیماری عروق کرونر و پیش‌بینی نوع مداخله: بیماران کاندید پیوند کلیه

Background: Uric acid as a final product of purine metabolism has a role of risk factor for cardiovascular disease with less clear mechanism in general population. The aim of this study was Assessing and finding association between uric acid levels and CAD as a risk factor in renal transplant candidates and if we can predict need to revascularization according to uric acid level as an important...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2004